LabLogic LIMS ADME Solutions

SoFie™ - Stop flow controller

The combination of HPLC separations and Radiochemical detection has been taken to a new level by LabLogic. Analysts can now achieve the lowest limits of detection in the industry with the SoFie stop flow controller and Laura software package. A fully automated system, designed, supported and maintained completely by LabLogic, the leaders in radiochemical detection.

Simplicity

SoFie replaces the requirement of time consuming and expensive Liquid Scintillation Counting of low level radionuclides. By using the optimized counting time in the radiochemical detector flow cell, the combination of the SoFie™ controller module and Laura™ software allows the radiochemical measurement to be entirely at the threshold and measurement level required by the user. With SoFie™ the radiochemist simply initiates a batch of samples and the system does the rest.

Single Point Control

With SoFie there is no requirement to collect column effluent for further analysis. The possibility of sample loss and incomplete transfer into a well plate or counting device cannot happen. SoFie automatically determines how long a particular HPLC peak should be measured in the radiochemical flow cell to achieve the correct quantitation of all peaks in the chromatogram.

Fraction collection followed by LSC is not required in order to achieve the desired Limit of Detection. LODs are simply preset in the SoFie method through the Laura software.

Multi vendor options with Laura

The Laura software package continues to expand its capability and now fully controls over 100 HPLC modules, Radiochemical Detection and Liquid Handling options. As with many HPLC systems, the SoFie stop flow option provides a fully validated and supported configuration from LabLogic.

The world’s leading pharmaceutical and contract research organizations use Laura to help achieve regulatory compliance in their discovery and research.

Features

• Accurate counting of low dpm samples
• Automated analysis, completely unattended operation
• Lowest limits of detection for radiochemical measurement
• Compatible with all radiochemical detectors
• Single point control for the complete system
• Prevents loss of volatile or thermolabile analytes
• Eliminates post run collection, preparation and recounting
• No requirement of exporting LSC data for analysis
• GxP compliant Laura software package

Set Up

There is no requirement to change any method parameter. All existing HPLC conditions remain the same. Retention times are consistent with excellent reproducibility. Additional method development is not required.

Optimized Counting at the right time all the time

Choice of Counting - Modes based on method or sample parameters

By Fraction - All HPLC effluent is counted in the flow cell to meet user LOD requirements.

By Count Zone - Users define multiple count zones to combine stop flow and traditional non-stop flow in the same run.